mapt mutations Search Results


cdna of the human tau splice variant 2n4r harbouring a double mutation (taup301l/r406w)  (Genoway Inc)
90
Genoway Inc cdna of the human tau splice variant 2n4r harbouring a double mutation (taup301l/r406w)
Cdna Of The Human Tau Splice Variant 2n4r Harbouring A Double Mutation (Taup301l/R406w), supplied by Genoway Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
cdna of the human tau splice variant 2n4r harbouring a double mutation (taup301l/r406w) - by Bioz Stars, 2026-03
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cdnas containing mutations v287e, k311a, v318e (tau-mbd)  (GenScript corporation)
90
GenScript corporation cdnas containing mutations v287e, k311a, v318e (tau-mbd)
Cdnas Containing Mutations V287e, K311a, V318e (Tau Mbd), supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cdnas containing mutations v287e, k311a, v318e (tau-mbd)/product/GenScript corporation
Average 90 stars, based on 1 article reviews
cdnas containing mutations v287e, k311a, v318e (tau-mbd) - by Bioz Stars, 2026-03
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tau p301s mutation  (Hasegawa Co Ltd)
90
Hasegawa Co Ltd tau p301s mutation
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Tau P301s Mutation, supplied by Hasegawa Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tau p301s mutation/product/Hasegawa Co Ltd
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tau p301s mutation - by Bioz Stars, 2026-03
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tau mutation  (Taconic Biosciences)
90
Taconic Biosciences tau mutation
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Tau Mutation, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tau mutation/product/Taconic Biosciences
Average 90 stars, based on 1 article reviews
tau mutation - by Bioz Stars, 2026-03
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tau gene mutation g389r  (Hasegawa Co Ltd)
90
Hasegawa Co Ltd tau gene mutation g389r
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Tau Gene Mutation G389r, supplied by Hasegawa Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tau gene mutation g389r/product/Hasegawa Co Ltd
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tau gene mutation g389r - by Bioz Stars, 2026-03
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full length human tau f8w, c291a, c322a mutations c-terminal his-tag  (Gene Universal Inc)
90
Gene Universal Inc full length human tau f8w, c291a, c322a mutations c-terminal his-tag
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Full Length Human Tau F8w, C291a, C322a Mutations C Terminal His Tag, supplied by Gene Universal Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/full length human tau f8w, c291a, c322a mutations c-terminal his-tag/product/Gene Universal Inc
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full length human tau f8w, c291a, c322a mutations c-terminal his-tag - by Bioz Stars, 2026-03
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pathogenic tau mutations  (Taconic Biosciences)
90
Taconic Biosciences pathogenic tau mutations
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Pathogenic Tau Mutations, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pathogenic tau mutations/product/Taconic Biosciences
Average 90 stars, based on 1 article reviews
pathogenic tau mutations - by Bioz Stars, 2026-03
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tau proteins with ftdp-17 mutations  (Hasegawa Co Ltd)
90
Hasegawa Co Ltd tau proteins with ftdp-17 mutations
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Tau Proteins With Ftdp 17 Mutations, supplied by Hasegawa Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tau proteins with ftdp-17 mutations/product/Hasegawa Co Ltd
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tau proteins with ftdp-17 mutations - by Bioz Stars, 2026-03
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methylation mimetics with tau mutation p301l  (Mimetics)
90
Mimetics methylation mimetics with tau mutation p301l
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Methylation Mimetics With Tau Mutation P301l, supplied by Mimetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/methylation mimetics with tau mutation p301l/product/Mimetics
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methylation mimetics with tau mutation p301l - by Bioz Stars, 2026-03
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neuropathologic variation in frontotemporal dementia due to the intronic tau 10(+16) mutation  (Janssen)
90
Janssen neuropathologic variation in frontotemporal dementia due to the intronic tau 10(+16) mutation
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Neuropathologic Variation In Frontotemporal Dementia Due To The Intronic Tau 10(+16) Mutation, supplied by Janssen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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neuropathologic variation in frontotemporal dementia due to the intronic tau 10(+16) mutation - by Bioz Stars, 2026-03
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tau with the s305n mutation  (Hasegawa Co Ltd)
90
Hasegawa Co Ltd tau with the s305n mutation
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Tau With The S305n Mutation, supplied by Hasegawa Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tau with the s305n mutation - by Bioz Stars, 2026-03
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mapt mutations  (Janssen)
90
Janssen mapt mutations
DSP-4 reduces NET IR in the LC of both WT and <t>P301S</t> mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.
Mapt Mutations, supplied by Janssen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mapt mutations - by Bioz Stars, 2026-03
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Image Search Results


DSP-4 reduces NET IR in the LC of both WT and P301S mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: DSP-4 reduces NET IR in the LC of both WT and P301S mice. WT and P301S mice were administered multiple doses of saline or DSP-4 (50 mg/kg, i.p.) and then assessed for behavior and pathology at various time points. A, Timeline of experiments. B, Representative immunofluorescence images. C–E, Quantification of the NET IR in the LC as percentage of total LC area. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 100 μm. *p < 0.05, compared with saline for that genotype.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Saline, Immunofluorescence

DSP-4 reduces NET IR and tissue NE content in the hippocampus. A, Representative immunofluorescence images. B–D, Quantification of NET IR in the hippocampus following saline or DSP-4 treatment in WT and P301S mice. E–G, Tissue NE concentrations in the hippocampus following saline or DSP-4 treatment in WT and P301S transgenic mice. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. *p < 0.05, compared with saline for that genotype. Hoechst, neuronal counterstain.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: DSP-4 reduces NET IR and tissue NE content in the hippocampus. A, Representative immunofluorescence images. B–D, Quantification of NET IR in the hippocampus following saline or DSP-4 treatment in WT and P301S mice. E–G, Tissue NE concentrations in the hippocampus following saline or DSP-4 treatment in WT and P301S transgenic mice. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. *p < 0.05, compared with saline for that genotype. Hoechst, neuronal counterstain.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Immunofluorescence, Saline, Transgenic Assay

Neither LC degeneration nor P301S impacts circadian locomotor activity. Data are mean ± SEM ambulations over 24 h in WT and P301S mice treated with saline or DSP-4; n = 7–12 per group. A, 4 months; B, 6 months; C, 10 months.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: Neither LC degeneration nor P301S impacts circadian locomotor activity. Data are mean ± SEM ambulations over 24 h in WT and P301S mice treated with saline or DSP-4; n = 7–12 per group. A, 4 months; B, 6 months; C, 10 months.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Activity Assay, Saline

Neither LC degeneration nor P301S impacts anxiety-like behavior in the open field test. Data are mean ± SEM (A–C) percentage time spent in center of the arena and (D–F) latency to leave the center of the arena in WT and P301S mice treated with saline or DSP-4; n = 7–12 per group.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: Neither LC degeneration nor P301S impacts anxiety-like behavior in the open field test. Data are mean ± SEM (A–C) percentage time spent in center of the arena and (D–F) latency to leave the center of the arena in WT and P301S mice treated with saline or DSP-4; n = 7–12 per group.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Saline

LC degeneration exacerbates spatial learning and memory in P301S mice in the Morris water maze. Data are mean ± SEM (A–C) latency to find the platform and (D–F) swim speed during 5 d of initial training in WT and P301S mice treated with saline or DSP-4. N = 8–12 per group. Two-way repeated-measures ANOVA (group × training day) with Dunnett's post hoc tests. *p < 0.05, compared with day 1 for that group. G–I, Data are mean ± SEM percentage time spent swimming during the probe trial in the quadrant that previously contained the platform. Dotted line indicates the percentage time an animal would spend swimming in the correct quadrant by chance (25%). N = 8–12 per group. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. #p < 0.05, compared with WT + saline.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC degeneration exacerbates spatial learning and memory in P301S mice in the Morris water maze. Data are mean ± SEM (A–C) latency to find the platform and (D–F) swim speed during 5 d of initial training in WT and P301S mice treated with saline or DSP-4. N = 8–12 per group. Two-way repeated-measures ANOVA (group × training day) with Dunnett's post hoc tests. *p < 0.05, compared with day 1 for that group. G–I, Data are mean ± SEM percentage time spent swimming during the probe trial in the quadrant that previously contained the platform. Dotted line indicates the percentage time an animal would spend swimming in the correct quadrant by chance (25%). N = 8–12 per group. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. #p < 0.05, compared with WT + saline.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Saline

LC degeneration impairs contextual, but not cued fear memory in P301S mice. Following 3 tone-shock pairings (A–C), fear behavior was recorded as percentage time spent freezing (mean ± SEM) following reexposure to the shock-associated context (D–F) or tone (G–I) in WT and P301S treated with saline or DSP-4. N = 8–12 per group. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. *p < 0.05, compared with WT + saline.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC degeneration impairs contextual, but not cued fear memory in P301S mice. Following 3 tone-shock pairings (A–C), fear behavior was recorded as percentage time spent freezing (mean ± SEM) following reexposure to the shock-associated context (D–F) or tone (G–I) in WT and P301S treated with saline or DSP-4. N = 8–12 per group. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. *p < 0.05, compared with WT + saline.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Saline

LC degeneration reduces survival in transgenic mice but does not alter physical neurodegenerative phenotypes. Quantification (mean ± SEM) of (A–C) hindlimb clasping and (D–F) kyphosis. N = 6–12 per group. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. *p < 0.05, compared with WT group with same treatment. ϕp < 0.05, compared with unlesioned group of the same genotype. G, Survival curve of WT and P301S mice treated with saline or DSP-4. N = 12 per group. Log-rank (Mantel–Cox) test. *p < 0.05, compared with all other groups.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC degeneration reduces survival in transgenic mice but does not alter physical neurodegenerative phenotypes. Quantification (mean ± SEM) of (A–C) hindlimb clasping and (D–F) kyphosis. N = 6–12 per group. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. *p < 0.05, compared with WT group with same treatment. ϕp < 0.05, compared with unlesioned group of the same genotype. G, Survival curve of WT and P301S mice treated with saline or DSP-4. N = 12 per group. Log-rank (Mantel–Cox) test. *p < 0.05, compared with all other groups.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Transgenic Assay, Saline

LC degeneration increases activated microglia in the hippocampus of P301S mice. A, Representative immunofluorescence images. B–D, Quantification of Iba1 IR in the hippocampus of WT and P301S mice following saline or DSP-4 treatment. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. #p < 0.05, compared with WT + saline. *p < 0.05, compared with P301S + saline. Iba1, microglia gene; Hoechst, neuronal counterstain.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC degeneration increases activated microglia in the hippocampus of P301S mice. A, Representative immunofluorescence images. B–D, Quantification of Iba1 IR in the hippocampus of WT and P301S mice following saline or DSP-4 treatment. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. #p < 0.05, compared with WT + saline. *p < 0.05, compared with P301S + saline. Iba1, microglia gene; Hoechst, neuronal counterstain.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Immunofluorescence, Saline

LC degeneration increases activated astrocytes in the hippocampus of P301S mice. A, Representative immunofluorescence images. B–D, Quantification of GFAP IR in the hippocampus of WT and P301S mice following saline or DSP-4 treatment. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. #p < 0.05, compared with WT + saline. *p < 0.05, compared with P301S + saline. Hoechst, neuronal counterstain.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC degeneration increases activated astrocytes in the hippocampus of P301S mice. A, Representative immunofluorescence images. B–D, Quantification of GFAP IR in the hippocampus of WT and P301S mice following saline or DSP-4 treatment. Two-way ANOVA (treatment × genotype) with Tukey's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. #p < 0.05, compared with WT + saline. *p < 0.05, compared with P301S + saline. Hoechst, neuronal counterstain.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Immunofluorescence, Saline

LC lesions promote neurodegeneration in the hippocampus of 10 month P301S mice. Representative images (A) and quantification of NeuN IR in the (B) CA1 and (C) CA3 regions of the hippocampus of WT and P301S mice treated with saline or DSP-4. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bars: Top, 200 μm; Bottom, 100 μm. *p < 0.05, compared with P301S + saline.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC lesions promote neurodegeneration in the hippocampus of 10 month P301S mice. Representative images (A) and quantification of NeuN IR in the (B) CA1 and (C) CA3 regions of the hippocampus of WT and P301S mice treated with saline or DSP-4. Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bars: Top, 200 μm; Bottom, 100 μm. *p < 0.05, compared with P301S + saline.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Saline

LC degeneration exacerbates hyperphosphorylated tau pathology in the dentate gyrus of P301S mice. Representative images of AT8 IR in the hippocampus of P301S mice following saline or DSP-4 treatment (A). Quantification of AT8 IR in CA3 (B), DG (C), and CA1 (D). Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. *p < 0.05. AT8, Phospho-tau (Ser202, Thr205), hyperphosphorylated tau; CV, cresyl violet, neuronal counterstain.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC degeneration exacerbates hyperphosphorylated tau pathology in the dentate gyrus of P301S mice. Representative images of AT8 IR in the hippocampus of P301S mice following saline or DSP-4 treatment (A). Quantification of AT8 IR in CA3 (B), DG (C), and CA1 (D). Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. *p < 0.05. AT8, Phospho-tau (Ser202, Thr205), hyperphosphorylated tau; CV, cresyl violet, neuronal counterstain.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Saline

LC degeneration exacerbates paired helical tau pathology in CA3 of P301S mice. Representative images of PHF1 IR in hippocampus of P301S mice following saline or DSP-4 treatment (A). Quantification of PHF1 IR in CA3 (B), DG (C), and CA1 (D). Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. *p < 0.05. PHF1, Phospho-tau (Ser396, Ser404), paired-helical filaments; CV, cresyl violet, neuronal counterstain.

Journal: The Journal of Neuroscience

Article Title: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

doi: 10.1523/JNEUROSCI.1483-17.2017

Figure Lengend Snippet: LC degeneration exacerbates paired helical tau pathology in CA3 of P301S mice. Representative images of PHF1 IR in hippocampus of P301S mice following saline or DSP-4 treatment (A). Quantification of PHF1 IR in CA3 (B), DG (C), and CA1 (D). Two-way ANOVA (treatment × genotype) with Sidak's post hoc tests. Data are mean ± SEM; n = 8–12 per group. Scale bar, 200 μm. *p < 0.05. PHF1, Phospho-tau (Ser396, Ser404), paired-helical filaments; CV, cresyl violet, neuronal counterstain.

Article Snippet: 10.1002/1531-8249(200007)48:1%3C126::AID-ANA21%3E3.0.CO;2-N [ PubMed ] [ CrossRef ] Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B. (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau .

Techniques: Saline